I’ve hurt my arm.
It’s nothing serious, but it is pretty painful. My doctor sent me for precautionary x-rays, which showed that everything is ok bonewise. She also gave me some anti-inflammatory tablets which she enthused about. In fact, she got quite carried away, reminding me of my wife when she discovers something else she can do with MS Excel.
Sheesh – accountants/doctors/other happy professionals.
Anyway, such was the doctor’s excitement over these tablets, I found that my scientific curiousity had been somewhat stimulated. I was almost quivering with mounting anticipation as I headed home from the pharmacy.
As soon as I got in and had removed the scrambled egg from the carpet, sofa and curtains (see: 2-year-old, having a), I went through the HUGE package insert. After a while, I realised that despite my years of medical training, I was struggling to understand a word of it. Then I realised I was looking at the Afrikaans side.
Etorikoksib word omvattend in die lewer gemataboliseer en minder as 1% van die dosis word in die urine as onveranderde geneesmiddel herwin.
Which, for a non-steroidal anti-inflammatory drug is pretty remarkable. And probably accounts for the mean oral bioavailability of 100%, which impressed me too.
Etoricoxib (the English spelling) is a COX-2 inhibitor. Stop sniggering at the back.
Hmm. That’s obviously enough of the exciting pharmacology.
I moved onto the section entitled Side Effects and Special Precautions. Yes – we’ve all seen renal failure, dyspepsia, nausea, dizziness, headache and the obligatory DEATH (“Don’t say we didn’t warn you, Mr Thousand!”). However, I was taken completely by surprise by what I read after those little gems. It was there I came across the best side effect I’ve ever heard of:
“detachment of the top layer of skin from the lower layers of the skin all over the body”
How cool is that? You too can be a snake for a day. Just don’t roll in salt afterwards.
I’m off out for a curry this evening – can you imagine the reaction as I moult gently into the shared naan bread?
“Hmm – this is a bit flaky tonight… not up to their usual standard.”